UFR de Pharmacie, Université de Tours

Nom : GUEIFFIER

Prénom : Alain

  Equipe de recherche

• Intitulé : Nutrition, Croissance et Cancer (N2C)
• Numéro : UMR INSERM U1069
• Thématiques : Lipide, cancer, nutrition, cachexie, acides gras poly-insaturés, profil lipidique, prolifération, migration, invasion, apoptose, canaux ioniques, cycle cellulaire, stress oxydant, vascularisation tumorale
• Mots clés : hétérocycles, azoté, synthèse, réactivité, anti-infectieux

  Principales publications

1. Z. BAHLAOUAN, M. ABARBRI, A. DUCHÈNE, J. THIBONNET, N. HENRY, C. ENGUEHARD-GUEIFFIER, A. GUEIFFIER ;  "Copper(I)-catalyzed preparation of new pyrano[3’,4’:4,5]imidazo[1,2-a]pyridine-1-one compounds under mild palladium-free conditions” ; Org. Biomol. Chem., 2011, 9(4), 1212-1218.
   
   
2. R. OUDOT, P. COSTES, H. ALLOUCHI, M. POUVREAU, M. ABARBRI, A. GUEIFFIER, C. ENGUEHARD-GUEIFFIER ; "Grignard reagent-promoted 6-endo-dig cyclization: instantaneous synthesis of original dipyrido[1,2-a:3’,4’-d]imidazole” ; Tetrahedron, 2011, 67(49), 9576-9581.
   
   
3. E. MOINE, C. DENEVAULT-SABOURIN, F. DEBIERRE-GROCKIEGO, L. SILPA, O. GORGETTE, J.C. BARALE, P. JACQUIET, F. BROSSIER, A. GUEIFFIER, I. DIMIER-POISSON, C. ENGUEHARD-GUEIFFIER ; "A small-molecule cell-based screen led to the identification of biphenylimidazoazines with highly potent and broad-spectrum anti-apicomplexan activity" ; Eur. J. Med. Chem., 2015, 89, 386-400.
   
   
4. C. ENGUEHARD-GUEIFFIER; P.O. DELAYE; M. PENICHON; C. DENEVAULT-SABOURIN; H. ALLOUCHI; A. GUEIFFIER ; "Domino 6-endo-dig Cyclization/Halogenation Reactions: Three-Component Synthesis of 1,3-Disubstituted 4-Haloimidazo[1,2-a:4,5-c']dipyridines" ; Synthesis, 2015, Ahead of Print.
   
   
5. E. MOINE; I. DIMIER-POISSON; C. ENGUEHARD-GUEIFFIER; C. LOGE; M. PENICHON; N. MOIRE; C. DELEHOUZE,; B. FOLL-JOSSELIN; S. RUCHAUD; S. BACH, A. GUEIFFIER; F. DEBIERRE-GROCKIEGO; C. DENEVAULT-SABOURIN ; "Development of new highly potent imidazo[1,2-b]pyridazines targeting Toxoplasma gondii calcium-dependent protein kinase 1" ; Eur. J. Med. Chem., 2015, 105, 85-105.